Department of Materials Science and Engineering, College of Materials, Xiamen University, Xiamen 361005, China; Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Department of Materials Science and Engineering, College of Materials, Xiamen University, Xiamen 361005, China.
Mater Sci Eng C Mater Biol Appl. 2014 Mar 1;36:146-51. doi: 10.1016/j.msec.2013.11.042. Epub 2013 Dec 7.
A simple method for preparing a new type of stable antibacterial agent was presented. Monodisperse poly(styrene-co-acrylic acid) (PSA) nanospheres, serving as matrices, were synthesized via soap-free emulsion polymerization. Field-emission scanning electron microscopy micrographs indicated that PSA nanospheres have interesting surface microstructures and well-controlled particle size distributions. Silver-loaded poly(styrene-co-acrylic acid) (PSA/Ag-NPs) nanocomposites were prepared in situ through interfacial reduction of silver nitrate with sodium borohydride, and further characterized by transmission electron microscopy and X-ray diffraction. Their effects on antibacterial activity including inhibition zone, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and bactericidal kinetics were evaluated. In the tests, PSA/Ag-NPs nanocomposites showed excellent antibacterial activity against both gram-positive Staphylococcus aureus and gram-negative Escherichia coli. These nanocomposites are considered to have potential application in antibacterial coatings on biomedical devices to reduce nosocomial infection rates.
提出了一种制备新型稳定抗菌剂的简单方法。通过无皂乳液聚合合成了单分散的苯乙烯-丙烯酸共聚物（PSA）纳米球作为基质。场发射扫描电子显微镜照片表明，PSA 纳米球具有有趣的表面微观结构和良好控制的粒径分布。通过硝酸银与硼氢化钠在界面处还原原位制备了载银的苯乙烯-丙烯酸共聚物（PSA/Ag-NPs）纳米复合材料，并通过透射电子显微镜和 X 射线衍射进一步进行了表征。评估了它们对抑菌圈、最小抑菌浓度（MIC）、最小杀菌浓度（MBC）和杀菌动力学等抗菌活性的影响。在测试中，PSA/Ag-NPs 纳米复合材料对革兰氏阳性金黄色葡萄球菌和革兰氏阴性大肠杆菌均表现出优异的抗菌活性。这些纳米复合材料被认为具有在生物医学器械上抗菌涂层的潜在应用，以降低医院感染率。
