Cyphert Erika L, von Recum Horst A
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Exp Biol Med (Maywood). 2017 Apr;242(8):788-798. doi: 10.1177/1535370216688572. Epub 2017 Jan 1.
Over the past 20 years, the field of antimicrobial medical device coatings has expanded nearly 30-fold with technologies shifting their focus from diffusion-only based (short-term antimicrobial eluting) coatings to long-term antimicrobial eluting and intrinsically antimicrobial functioning materials. A variety of emergent coatings have been developed with the goal of achieving long-term antimicrobial activity in order to mitigate the risk of implanted device failure. Specifically, the coatings can be grouped into two categories: those that use antibiotics in conjunction with a polymer coating and those that rely on the intrinsic properties of the material to kill or repel bacteria that come into contact with the surface. This review covers both long-term drug-eluting and non-eluting coatings and evaluates the inherent advantages and disadvantages of each type while providing an overview of variety applications that the coatings have been utilized in. Impact statement This work provides an overview, with advantages and limitations of the most recently developed antibacterial coating technologies, enabling other researchers in the field to more easily determine which technology is most advantageous for them to further develop and pursue.
在过去20年里，抗菌医疗器械涂层领域已扩展近30倍，技术重点已从仅基于扩散的（短期抗菌洗脱）涂层转向长期抗菌洗脱和具有固有抗菌功能的材料。为了降低植入设备故障的风险，已开发出多种具有长期抗菌活性目标的新型涂层。具体而言，这些涂层可分为两类：一类是将抗生素与聚合物涂层结合使用的涂层，另一类是依靠材料的固有特性来杀死或排斥接触表面的细菌的涂层。本综述涵盖了长期药物洗脱涂层和非洗脱涂层，评估了每种类型的固有优缺点，同时概述了这些涂层已应用的各种领域。影响声明 这项工作概述了最新开发的抗菌涂层技术的优点和局限性，使该领域的其他研究人员能够更轻松地确定哪种技术对他们进一步开发和探索最具优势。
