Chou Yu-Hsiang, Pan Szu-Yu, Yang Chian-Huei, Lin Shuei-Liong
Renal Division, Department of Internal Medicine, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin County, Taiwan; Graduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan; Renal Division, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Renal Division, Department of Internal Medicine, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin County, Taiwan; Renal Division, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
J Formos Med Assoc. 2014 Apr;113(4):201-9. doi: 10.1016/j.jfma.2013.12.001. Epub 2014 Jan 13.
Kidney disease is an escalating burden all over the world. In addition to preventing kidney injury, regenerating damaged renal tissue is as important as to retard the progression of chronic kidney disease to end stage renal disease. Although the kidney is a delicate organ and has only limited regenerative capacity compared to the other organs, an increasing understanding of renal development and renal reprogramming has kindled the prospects of regenerative options for kidney disease. Here, we will review the advances in the kidney regeneration including the manipulation of renal tubular cells, fibroblasts, endothelial cells, and macrophages in renal disease. Several types of stem cells, such as bone marrow-derived cells, adipocyte-derived mesenchymal stem cells, embryonic stem cells, and induced pluripotent stem cells are also applied for renal regeneration. Endogenous or lineage reprogrammed renal progenitor cells represent an attractive possibility for differentiation into multiple renal cell types. Angiogenesis can ameliorate hypoxia and renal fibrosis. Based on these studies and knowledge, we hope to innovate more reliable pharmacological or biotechnical methods for kidney regeneration medicine.
肾脏疾病在全球范围内的负担正不断加重。除了预防肾损伤外，再生受损的肾组织与延缓慢性肾脏病进展至终末期肾病同样重要。尽管肾脏是一个脆弱的器官，与其他器官相比其再生能力有限，但对肾脏发育和肾脏重编程的认识不断增加，为肾脏疾病的再生治疗带来了希望。在此，我们将综述肾脏再生的进展，包括在肾脏疾病中对肾小管细胞、成纤维细胞、内皮细胞和巨噬细胞的调控。几种类型的干细胞，如骨髓来源的细胞、脂肪来源的间充质干细胞、胚胎干细胞和诱导多能干细胞也被应用于肾脏再生。内源性或谱系重编程的肾祖细胞分化为多种肾细胞类型具有很大的潜力。血管生成可以改善缺氧和肾纤维化。基于这些研究和知识，我们希望为肾脏再生医学创新出更可靠的药理学或生物技术方法。
