Wang Shaoyin, Zhu Xiancui, Chai Zhuo, Wang Shaowu
Department of Chemistry, Wannan Medical College, Wuhu, Anhui 241002, P. R. China.
Org Biomol Chem. 2014 Feb 28;12(8):1351-6. doi: 10.1039/c3ob42324g.
Polysubstituted pyrroles were regioselectively synthesized in moderate to good yields via the copper acetate-catalyzed [3 + 2] annulation reaction of readily accessible aziridines and nitroalkenes. This reaction was proposed to proceed through a key azomethine ylide intermediate generated by selective C-C bond cleavage of the aziridine followed by annulation with nitroalkenes under aerobic conditions.
通过醋酸铜催化易于获得的氮丙啶和硝基烯烃的[3 + 2]环化反应，以中等至良好的产率区域选择性地合成了多取代吡咯。该反应被认为是通过氮丙啶的选择性C-C键裂解生成关键的甲亚胺叶立德中间体，然后在有氧条件下与硝基烯烃环化而进行的。
