Maggi C A, Santicioli P, Parlani M, Astolfi M, Patacchini R, Meli A
Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy.
J Pharm Pharmacol. 1987 Aug;39(8):653-5. doi: 10.1111/j.2042-7158.1987.tb03447.x.
The contractile response to substance P in-vitro is greater in strips of guinea-pig bladder freed of mucosa than in normal strips, while the response to field stimulation, histamine or KCl is unaffected by the presence of mucosa. Substance P has no inhibitory effect on histamine-induced contractions of the guinea-pig bladder. These findings support the possibility that the presence of mucosa may reduce accessibility of substance P to the muscle layer.
在体外，去除黏膜的豚鼠膀胱条对P物质的收缩反应比正常膀胱条更大，而对场刺激、组胺或氯化钾的反应不受黏膜存在与否的影响。P物质对组胺诱导的豚鼠膀胱收缩没有抑制作用。这些发现支持了黏膜的存在可能会降低P物质与肌层接触的可能性这一观点。
