Khizer Zara, Sadia Amina, Sharma Raman, Farhaj Samia, Nirwan Jorabar Singh, Kakadia Pratibha G, Hussain Talib, Yousaf Abid Mehmood, Shahzad Yasser, Conway Barbara R, Ghori Muhammad Usman
Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield HD1 3DH, UK.
District Headquarter Hospital, Sahiwal 57000, Pakistan.
Pharmaceuticals (Basel). 2021 Apr 26;14(5):409. doi: 10.3390/ph14050409.
Overactive bladder syndrome (OAB) is characterised by urgency symptoms, with or without urgency incontinence, usually with frequency and nocturia and severely affects the quality of life. This systematic review evaluates the various drug delivery strategies used in practice to manage OAB. Advanced drug delivery strategies alongside traditional strategies were comprehensively analysed and comparatively evaluated. The present review was conducted according to the preferred reporting items for systematic reviews and meta-analyses guidelines. A total of 24 studies reporting the development of novel formulations for the treatment of OAB were considered eligible and were further categorised according to the route of drug administration. The review found that various drug delivery routes (transdermal, intravesicular, oral, vaginal and intramuscular) are used for the administration of drugs for managing OAB, however, the outcomes illustrated the marked potential of transdermal drug delivery route. The findings of the current review are expected to be helpful for pharmaceutical scientists to better comprehend the existing literature and challenges and is anticipated to provide a basis for designing and fabricating novel drug delivery systems to manage OAB.
膀胱过度活动症（OAB）的特征是尿急症状，伴有或不伴有急迫性尿失禁，通常还伴有尿频和夜尿症，严重影响生活质量。本系统评价评估了实践中用于管理OAB的各种药物递送策略。对先进的药物递送策略与传统策略进行了全面分析和比较评估。本评价是根据系统评价和Meta分析的首选报告项目指南进行的。共有24项报告用于治疗OAB的新型制剂开发的研究被认为符合条件，并根据给药途径进一步分类。该评价发现，各种药物递送途径（透皮、膀胱内、口服、阴道和肌肉注射）都用于OAB治疗药物的给药，然而，结果表明透皮药物递送途径具有显著潜力。预计本次评价的结果将有助于药物科学家更好地理解现有文献和挑战，并有望为设计和制造用于管理OAB的新型药物递送系统提供依据。
