Fujimura Akio
Division of Clinical Pharmacology, Department of pharmacology, Jichi Medical University School of Medicine.
Nihon Rinsho. 2013 Dec;71(12):2097-101.
Chronotherapy integrates chronoeffective and chronotoxic data to enhance an effectiveness and tolerance of a drug by choosing optimal dosing-time. Chronotherapy is already performed in several diseases such as hypertension, osteoporosis, dyslipidemia and malignant diseases, and improves the prognosis of these patients. However, it is still a new concept for physicians. Efforts are needed to take chronotherapy into dosage regimen by physicians, who have a major role in providing the benefits of chronotherapy to their patients. In addition, chronotherapy studies are not requested for drug evaluations by the regulatory authorities. However, preliminary screening of new drugs for their chronotherapeutic potential is a way of enhancing the research and development in pharmaceutical industries.
时间治疗学整合了时间效应和时间毒性数据，通过选择最佳给药时间来提高药物的有效性和耐受性。时间治疗学已应用于多种疾病，如高血压、骨质疏松症、血脂异常和恶性疾病，并改善了这些患者的预后。然而，对医生来说，这仍然是一个新概念。医生需要努力将时间治疗学纳入给药方案，他们在为患者提供时间治疗学益处方面起着主要作用。此外，监管机构在药物评估中并不要求进行时间治疗学研究。然而，对新药进行时间治疗潜力的初步筛选是加强制药行业研发的一种方式。
