Trautvetter Ulrike, Neef Nadja, Leiterer Matthias, Kiehntopf Michael, Kratzsch Jürgen, Jahreis Gerhard
Department of Nutritional Physiology, Institute of Nutrition, Friedrich Schiller University of Jena, Dornburger Str, 24, D-07743, Jena, Germany.
Nutr J. 2014 Jan 17;13:6. doi: 10.1186/1475-2891-13-6.
The aim of the present study was to determine the effect of calcium phosphate and/or vitamin D₃ on bone and mineral metabolism.
Sixty omnivorous healthy subjects participated in the double-blind, placebo-controlled parallel designed study. Supplements were tricalcium phosphate (CaP) and cholecalciferol (vitamin D₃). At the beginning of the study (baseline), all subjects documented their normal nutritional habits in a dietary record for three successive days. After baseline, subjects were allocated to three intervention groups: CaP (additional 1 g calcium/d), vitamin D₃ (additional 10 μg/d) and CaP + vitamin D₃. In the first two weeks, all groups consumed placebo bread, and afterwards, for eight weeks, the test bread according to the intervention group. In the last week of each study period (baseline, placebo, after four and eight weeks of intervention), a faecal (three days) and a urine (24 h) collection and a fasting blood sampling took place. Calcium, phosphorus, magnesium and iron were determined in faeces, urine and blood. Bone formation and resorption markers were analysed in blood and urine.
After four and eight weeks, CaP and CaP + vitamin D₃ supplementations increased faecal excretion of calcium and phosphorus significantly compared to placebo. Due to the vitamin D₃ supplementations (vitamin D₃, CaP + vitamin D₃), the plasma 25-(OH)D concentration significantly increased after eight weeks compared to placebo. The additional application of CaP led to a significant increase of the 25-(OH)D concentration already after four weeks. Bone resorption and bone formation markers were not influenced by any intervention.
Supplementation with daily 10 μg vitamin D₃ significantly increases plasma 25-(OH)D concentration. The combination with daily 1 g calcium (as CaP) has a further increasing effect on the 25-(OH)D concentration. Both CaP alone and in combination with vitamin D₃ have no beneficial effect on bone remodelling markers and on the metabolism of calcium, phosphorus, magnesium and iron.
NCT01297023.
本研究的目的是确定磷酸钙和/或维生素D₃对骨骼和矿物质代谢的影响。
60名杂食性健康受试者参与了这项双盲、安慰剂对照的平行设计研究。补充剂为磷酸三钙（CaP）和胆钙化醇（维生素D₃）。在研究开始时（基线），所有受试者在连续三天的饮食记录中记录他们正常的营养习惯。基线后，受试者被分配到三个干预组：CaP（额外补充1克钙/天）、维生素D₃（额外补充10微克/天）和CaP + 维生素D₃。在前两周，所有组食用安慰剂面包，之后，持续八周，根据干预组食用试验面包。在每个研究阶段的最后一周（基线、安慰剂期、干预四周和八周后），进行粪便（三天）和尿液（24小时）收集以及空腹采血。测定粪便、尿液和血液中的钙、磷、镁和铁。分析血液和尿液中的骨形成和骨吸收标志物。
四周和八周后，与安慰剂相比，补充CaP和CaP + 维生素D₃显著增加了粪便中钙和磷的排泄。由于补充维生素D₃（维生素D₃组、CaP + 维生素D₃组），八周后血浆25 -（OH）D浓度与安慰剂相比显著增加。额外补充CaP在四周后就导致25 -（OH）D浓度显著增加。骨吸收和骨形成标志物不受任何干预的影响。
每日补充10微克维生素D₃可显著提高血浆25 -（OH）D浓度。与每日1克钙（以CaP形式）联合使用对25 -（OH）D浓度有进一步的升高作用。单独使用CaP以及与维生素D₃联合使用对骨重塑标志物以及钙、磷、镁和铁的代谢均无有益影响。
NCT01297023。
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