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间充质干细胞在肌肉骨骼医学中的临床挑战与机遇

Clinical challenges and opportunities of mesenchymal stem cells in musculoskeletal medicine.

作者信息

Centeno Christopher J

机构信息

The Centeno-Schultz Clinic, 403 Summit Boulevard, Unit 201, Broomfield, CO 80021-8253(∗).

出版信息

PM R. 2014 Jan;6(1):70-7. doi: 10.1016/j.pmrj.2013.08.612.

DOI:10.1016/j.pmrj.2013.08.612
PMID:24439149
Abstract

The use of stem cells in orthopedics has been researched for many years, with robust animal data that show efficacy in cartilage healing, tendon repair, and intervertebral disk treatment. Early clinical data are also just starting to be published, and these results are encouraging. Safety data in large case series, some that lasted for many years, have also been published. The field of tissue engineering with stem cells in musculoskeletal impairments has the potential to reduce morbidity and improve clinical outcomes. The regulatory environment for this area of medicine is still developing.

摘要

干细胞在骨科领域的应用已被研究多年,有大量可靠的动物数据表明其在软骨愈合、肌腱修复和椎间盘治疗方面具有疗效。早期临床数据也刚刚开始发表,这些结果令人鼓舞。一些持续多年的大病例系列的安全性数据也已公布。在肌肉骨骼损伤中利用干细胞的组织工程领域有潜力降低发病率并改善临床结果。该医学领域的监管环境仍在发展中。

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