同时性原发性结直肠癌与结直肠肝转移瘤切除术的安全性和疗效评估
Evaluation of the safety and efficacy of simultaneous resection of primary colorectal cancer and synchronous colorectal liver metastases.
作者信息
Yoshioka Ryuji, Hasegawa Kiyoshi, Mise Yoshihiro, Oba Masaru, Aoki Taku, Sakamoto Yoshihiro, Sugawara Yasuhiko, Sunami Eiji, Watanabe Toshiaki, Kokudo Norihiro
机构信息
Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Division of Surgical Oncology, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
出版信息
Surgery. 2014 Mar;155(3):478-85. doi: 10.1016/j.surg.2013.10.015. Epub 2013 Oct 14.
BACKGROUND
It remains unclear whether primary colorectal cancer and synchronous liver metastases (SLMs) should be resected simultaneously or with a staged procedure.
METHODS
We reviewed the short-term outcomes of 127 patients who underwent simultaneous resection of primary colorectal cancer and SLM at our institution from January 1993 to December 2011.
RESULTS
The proportion of simultaneous resections was 84.7% (127 of 150 patients). There was no postoperative mortality, and the postoperative complication rate was 61.4%. Major complications occurred in 23 (18.2%) patients, and anastomotic failure occurred in 2 (1.6%). The 3-, 5-, and 10-year overall survival rates were 74%, 64%, and 52%, respectively. The median recurrence-free survival period was 7.0 months (95% confidence interval, 4.5-9.5 months) and the 5-year recurrence-free survival rate was 17%.
CONCLUSION
Simultaneous resection can be performed safely in patients with colorectal cancer and SLM.
背景
原发性结直肠癌和同时性肝转移瘤（SLMs）是应同期切除还是分期手术仍不明确。
方法
我们回顾了1993年1月至2011年12月在我院接受原发性结直肠癌和SLM同期切除的127例患者的短期结局。
结果
同期切除的比例为84.7%（150例患者中的127例）。无术后死亡，术后并发症发生率为61.4%。23例（18.2%）患者发生严重并发症，2例（1.6%）发生吻合口失败。3年、5年和10年总生存率分别为74%、64%和52%。无复发生存期的中位数为7.0个月（95%置信区间，4.5 - 9.5个月），5年无复发生存率为17%。
结论
结直肠癌合并SLM的患者可安全地进行同期切除。
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