Kleinschmidt A, Bear M F, Singer W
Department of Neurophysiology, Max Planck Institute for Brain Research, Frankfurt, Federal Republic of Germany.
Science. 1987 Oct 16;238(4825):355-8. doi: 10.1126/science.2443978.
Intracortical infusion of the "N-methyl-D-aspartate" (NMDA) receptor blocker D,L-2-amino-5-phosphonovaleric acid (APV) renders kitten striate cortex resistant to the effects of monocular deprivation. In addition, 1 week of continuous APV treatment (50 nanomoles per hour) produces a striking loss of orientation selectivity in area 17. These data support the hypothesis that crucial variables for the expression of activity-dependent synaptic modifications are a critical level of postsynaptic activation and calcium entry through ion channels linked to NMDA receptors.
向小猫的视皮层内注入“N-甲基-D-天冬氨酸”（NMDA）受体阻断剂D，L-2-氨基-5-磷酸缬氨酸（APV），可使视皮层对单眼剥夺效应产生抗性。此外，连续1周进行APV治疗（每小时50纳摩尔）会导致17区的方向选择性显著丧失。这些数据支持了这样一种假说，即活动依赖性突触修饰表达的关键变量是突触后激活的临界水平以及通过与NMDA受体相连的离子通道进入的钙。
