Bischof P
Département de Gynécologie, Université de Genève, Suisse.
Ann Endocrinol (Paris). 1987;48(4):289-99.
This review article summarizes our knowledge about three proteins associated to human pregnancy: placental protein 12 and 14 (PP12, PP14) and pregnancy-associated plasma protein-A (PAPP-A). These have in common their origin since all three seem to be produced by the pregnant endometrium (although not exclusively). Two of these proteins (PP12, PP14) have been described independently by many authors and are thus known, under many different names. For each protein their biochemical properties, their origin and regulation, their biological properties, as well as potential clinical applications, are discussed in detail. The clinical applications of PP12, PP14 and PAPP-A measurements are not only limited to uterine pathologies but also include cancer (tumour markers) and pregnancy (hydatidiform moles and extra-uterine pregnancies). This review is the first complete and comparative study of these three proteins, but many more questions are asked than solved. This is essentially due to the fact that human endometrial proteins is a rather new subject.
胎盘蛋白12和14（PP12、PP14）以及妊娠相关血浆蛋白-A（PAPP-A）。它们的共同之处在于起源，因为这三种蛋白似乎均由妊娠子宫内膜产生（尽管并非唯一来源）。其中两种蛋白（PP12、PP14）已被众多作者分别描述，因此有许多不同的名称。本文将详细讨论每种蛋白的生化特性、起源与调控、生物学特性以及潜在的临床应用。PP12、PP14和PAPP-A检测的临床应用不仅限于子宫疾病，还包括癌症（肿瘤标志物）和妊娠（葡萄胎和宫外孕）。这篇综述是对这三种蛋白的首次全面比较研究，但提出的问题远多于解决的问题。这主要是因为人类子宫内膜蛋白是一个相当新的课题。
