海绵共生真菌 Aspergillus versicolor Hmp-48 的细胞毒性多酚。
Cytotoxic polyphenols from a sponge-associated fungus Aspergillus versicolor Hmp-48.
机构信息
Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, P. R. China, (phone: +86-88087740); School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China.
出版信息
Chem Biodivers. 2014 Jan;11(1):133-9. doi: 10.1002/cbdv.201300115.
A new dibenzo[1,4]dioxin 1, and two new prenylated diphenyl ethers, 2 and 3, together with six known compounds, 4-9, were isolated from a sponge-associated fungus Aspergillus versicolor Hmp-F48 by bioactivity-guided fractionation. Their structures were elucidated by 1D- and 2D-NMR, and MS analyses. The compounds showed potent cell growth inhibitory activities against HL-60 cell line.
一种新的二苯并[1,4]二恶英 1，以及两种新的芳樟醇基二苯醚 2 和 3，与六种已知化合物 4-9 一起，从海绵共生真菌 Aspergillus versicolor Hmp-F48 中通过活性导向分离得到。它们的结构通过 1D- 和 2D-NMR 以及 MS 分析得到阐明。这些化合物对 HL-60 细胞系表现出强烈的细胞生长抑制活性。
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