State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China.
Org Lett. 2010 Mar 19;12(6):1208-11. doi: 10.1021/ol902974j.
A new cytotoxic triterpenoid, schinalactone A (1), together with two new biogenetically related compounds, schinalactones B (2) and C (3), has been isolated from the roots and stems of Schisandra sphenanthera.Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 1 and 2 showed significant cytotoxicity against PANC-1 cell lines with IC(50) values of 5.9 and 4.1 microM, respectively. A plausible biosynthetic pathway of 1 was also postulated.
从华中五味子的根和茎中分离得到了一种新的细胞毒素三萜烯，即五味子内酯 A（1），以及另外两种生物相关的化合物，五味子内酯 B（2）和 C（3）。根据广泛的光谱分析确定了它们的结构。化合物 1 和 2 对 PANC-1 细胞系表现出显著的细胞毒性，IC50 值分别为 5.9 和 4.1 μM。还提出了 1 的可能生物合成途径。
