五味子甲素 A，一种来自五味子的新型细胞毒三萜。

Schinalactone A, a new cytotoxic triterpenoid from Schisandra sphenanthera.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China.

出版信息

Org Lett. 2010 Mar 19;12(6):1208-11. doi: 10.1021/ol902974j.

DOI:10.1021/ol902974j

PMID:20180522

Abstract

A new cytotoxic triterpenoid, schinalactone A (1), together with two new biogenetically related compounds, schinalactones B (2) and C (3), has been isolated from the roots and stems of Schisandra sphenanthera.Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 1 and 2 showed significant cytotoxicity against PANC-1 cell lines with IC(50) values of 5.9 and 4.1 microM, respectively. A plausible biosynthetic pathway of 1 was also postulated.

摘要

从华中五味子的根和茎中分离得到了一种新的细胞毒素三萜烯，即五味子内酯 A（1），以及另外两种生物相关的化合物，五味子内酯 B（2）和 C（3）。根据广泛的光谱分析确定了它们的结构。化合物 1 和 2 对 PANC-1 细胞系表现出显著的细胞毒性，IC50 值分别为 5.9 和 4.1 μM。还提出了 1 的可能生物合成途径。