Endocrine Unit, Third Department of Internal Medicine, Medical School University of Athens, Sotiria Hospital, Athens, Greece.
J Endocrinol Invest. 2013 Dec;36(11):1105-11. doi: 10.1007/BF03346762.
Polycystic ovary syndrome (PCOS) is a complex and enigmatic syndrome of unknown origin and etiology enclosing a broad spectrum of phenotypic manifestations. PCOS pathophysiology combines reproductive and metabolic abnormalities into a heterogeneous disorder that has pervasive and devastating health consequences. Inquiring the generative roots of the syndrome, it has become increasingly apparent the role of the environment as a determinant factor. Experimental exposure to industrial endocrine disruptors has been related with the impairment of normal reproductive function and metabolic regulation possibly favoring the development of or aggravating PCOS-resembling clinical disorders. Industrial chemicals may reflect the contributing role of an unfavorable environment to unveil PCOS characteristics in genetically predisposed individuals or further deteriorate the hormonal and fertility imbalances of PCOS-affected females.
多囊卵巢综合征（PCOS）是一种复杂且神秘的综合征，其病因不明，临床表现广泛。PCOS 的病理生理学将生殖和代谢异常结合为一种异质性疾病，对健康有广泛而严重的影响。探究该综合征的起源，环境作为决定因素的作用越来越明显。实验暴露于工业内分泌干扰物与正常生殖功能和代谢调节的损害有关，可能有利于 PCOS 样临床疾病的发展或加重。工业化学品可能反映了不利环境的促成作用，从而在遗传易感性个体中揭示 PCOS 的特征，或进一步恶化 PCOS 女性的激素和生育失衡。
