Hartaigh Bríain ó, Allore Heather G, Trentalange Mark, McAvay Gail, Pilz Stefan, Dodson John A, Gill Thomas M
Department of Internal Medicine/Geriatrics, Yale School of Medicine, USA
Department of Internal Medicine/Geriatrics, Yale School of Medicine, USA.
Eur J Prev Cardiol. 2015 Apr;22(4):527-34. doi: 10.1177/2047487313519932. Epub 2014 Jan 20.
An increased resting heart rate (RHR) has long been associated with unhealthy life. Nevertheless, it remains uncertain whether time-varying measurements of RHR are predictive of mortality in older persons.
The purpose of this study was to assess the relationship between repeated measurements of RHR and risk of death from all causes among older adults.
We evaluated repeat measurements of resting heart rate among 5691 men and women (aged 65 years or older) enrolled in the Cardiovascular Health Study. RHR was measured annually for six consecutive years by validated electrocardiogram. All-cause mortality was confirmed by a study-wide Mortality Review Committee using reviews of obituaries, death certificates and hospital records, interviews with attending physicians, and next-of-kin.
Of the study cohort, 974 (17.1%) participants died. Each 10 beat/min increment in RHR increased the risk of death by 33% (adjusted hazard ratio, 95% confidence interval (CI) = 1.33, 1.26-1.40). Similar results were observed (adjusted hazard ratio, 95% CI = 2.21, 1.88-2.59) when comparing the upper-most quartile of RHR (mean = 81 beats/min) with the lowest (mean = 53 beats/min). Compared with participants whose RHR was consistently ≤65 beats/min during the study period, the risk of death increased monotonically for each 10 beat/min (consistent) increment in RHR, with adjusted hazard ratios (95% CI) ranging from 1.30 (1.23-1.37) for 75 beats/min to 4.78 (3.49-6.52) for 125 beats/min.
Elevations in the RHR over the course of six years are associated with an increased risk of all-cause mortality among older adults.
静息心率（RHR）升高长期以来一直与不健康的生活方式相关。然而，RHR的动态测量是否能预测老年人的死亡率仍不确定。
本研究的目的是评估老年人重复测量RHR与全因死亡风险之间的关系。
我们评估了参加心血管健康研究的5691名男性和女性（年龄65岁及以上）的静息心率重复测量值。通过经验证的心电图连续六年每年测量RHR。全因死亡率由全研究范围的死亡率审查委员会通过查阅讣告、死亡证明和医院记录、与主治医生面谈以及与近亲面谈来确认。
在研究队列中，974名（17.1%）参与者死亡。RHR每增加10次/分钟，死亡风险增加33%（调整后的风险比，95%置信区间（CI）=1.33，1.26 - 1.40）。当比较RHR最高四分位数（平均 = 81次/分钟）与最低四分位数（平均 = 53次/分钟）时，观察到类似结果（调整后的风险比，95% CI = 2.21，1.88 - 2.59）。与研究期间RHR始终≤65次/分钟的参与者相比，RHR每持续增加10次/分钟，死亡风险单调增加，调整后的风险比（95% CI）范围从75次/分钟时的1.30（1.23 - 1.37）到125次/分钟时的4.78（3.49 - 6.52）。
在六年期间RHR升高与老年人全因死亡风险增加相关。
