Graduate School, North China University of Science and Technology, Tangshan, China.
Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, China.
Sci Rep. 2017 Jan 9;7:40212. doi: 10.1038/srep40212.
The relationship between cumulative exposure to resting heart rate (cumRHR) and mortality remain unclear in the general population. In the Kailuan cohort study, resting heart rate (RHR) was repeatedly measured at baseline and at years 2 and 4 by electrocardiogram among 47,311 adults aged 48.70 ± 11.68. The cumRHR was defined as the summed average RHR between two consecutive examinations multiplied by the time interval between with two examinations [(beats/min) * year]. A higher RHR was defined as ≥80 beats/min, and the number of visits with a higher RHR was counted. During a median of 4.06 years of follow-up, a total of 1,025 participants died. After adjusting for major traditional cardiovascular risk factors and baseline RHR, the hazard ratio for the highest versus lowest quartile of cumRHR was 1.39 (95% CI: 1.07-1.81) for all-cause mortality. Each 1-SD increment in cumRHR was associated with a 37% (HR: 1.37, 95% CI: 1.23-1.52) increased risk of death and displayed a J-shaped relationship. Compared with no exposure, adults who had a higher RHR at all 3 study visits were associated with a 1.86-fold higher risk (95% CI: 1.33-2.61) of mortality. In summary, cumulative exposure to higher RHR is independently associated with an increased risk of mortality.
静息心率（RHR）的累积暴露与全因死亡率之间的关系在普通人群中尚不清楚。在开滦队列研究中，在基线和第 2 年和第 4 年，通过心电图对 47311 名年龄在 48.70±11.68 岁的成年人重复测量了静息心率（RHR）。RHR 的累积暴露定义为两次连续检查之间的平均 RHR 乘以两次检查之间的时间间隔[（次/分）*年]。RHR 较高定义为≥80 次/分，并计算较高 RHR 的就诊次数。在中位数为 4.06 年的随访期间，共有 1025 名参与者死亡。在调整主要传统心血管危险因素和基线 RHR 后，最高与最低 cumRHR 四分位数的全因死亡率的危险比为 1.39（95%CI：1.07-1.81）。cumRHR 的每 1-SD 增加与死亡风险增加 37%（HR：1.37，95%CI：1.23-1.52）相关，并呈 J 形关系。与无暴露相比，在所有 3 次研究就诊时 RHR 较高的成年人的死亡风险增加 1.86 倍（95%CI：1.33-2.61）。总之，较高 RHR 的累积暴露与死亡率增加独立相关。
