在体外从马肺和白细胞中释放的过敏反应化学介质（组胺、5-羟色胺和慢反应物质-A）。
Chemical mediators of anaphylaxis (histamine, 5-HT, and SRS-A) released from horse lung and leukocytes in vitro.
作者信息
Burka J F, Deline T R, Holroyde M C, Eyre P
出版信息
Res Commun Chem Pathol Pharmacol. 1976 Mar;13(3):379-88.
Horses were sensitized to bovine plasma in Freund's complete adjuvant. Leukocytes, separated from venous blood, yielded histamine upon incubation with bovine plasma. Ioslated lung fragments incubated with bovine plasma liberated histamine and 5-HT, but not SRS-A. Pulmonary veins obtained from the same animals contracted to histamine, 5-HT and to antigen (Schultz-Dale reaction). Histamine and 5-HT probably contribute to immediate-type hypersensitivity in horses whereas the role of SRS-A is not proved.
用弗氏完全佐剂使马对牛血浆致敏。从静脉血中分离出的白细胞在与牛血浆孵育时会产生组胺。与牛血浆一起孵育的离体肺碎片会释放组胺和5-羟色胺，但不会释放慢反应物质-A。从同一动物身上获取的肺静脉会对组胺、5-羟色胺和抗原产生收缩反应（舒尔茨-戴尔反应）。组胺和5-羟色胺可能导致马的速发型超敏反应，而慢反应物质-A的作用尚未得到证实。
Zotero 插件