Guedes-Martins L, Cunha A, Saraiva J, Gaio R, Macedo F, Almeida H
1] Departamento de Biologia Experimental, Faculdade de Medicina da Universidade do Porto, 4200-319 Porto, Portugal [2] IBMC-Instituto de Biologia Molecular e Celular, 4150-180 Porto, Portugal [3] Centro Hospitalar do Porto EPE, Departamento da Mulher e da Medicina Reprodutiva, Largo Prof. Abel Salazar, 4099-001 Porto, Portugal.
Centro Hospitalar do Porto EPE, Departamento da Mulher e da Medicina Reprodutiva, Largo Prof. Abel Salazar, 4099-001 Porto, Portugal.
Sci Rep. 2014 Jan 21;4:3785. doi: 10.1038/srep03785.
The objective of this work was to compare Doppler flows pulsatility index (PI) and resistance indexes (RI) of uterine and internal iliac arteries during pregnancy in low risk women and in those with stage-1 essential hypertension. From January 2010 and December 2012, a longitudinal and prospective study was carried out in 103 singleton uneventful pregnancies (72 low-risk pregnancies and 31 with stage 1 essential hypertension)at the 1(st), 2(nd) and 3(rd) trimesters. Multiple linear regression models, fitted using generalized least squares and whose errors were allowed to be correlated and/or have unequal variances, were employed; a model for the relative differences of both arteries impedance was utilized. In both groups, uterine artery PI and RI exhibited a gestational age related decreasing trend whereas internal iliac artery PI and RI increased. The model testing the hemodynamic adaptation in women with and without hypertension showed similar trend. Irrespective of blood pressure conditions, the internal iliac artery resistance pattern contrasts with the capacitance pattern of its immediate pelvic division, suggesting a pregnancy-related regulatory mechanism in the pelvic circulation.
这项工作的目的是比较低风险孕妇和1期原发性高血压孕妇孕期子宫动脉和髂内动脉的多普勒血流搏动指数(PI)和阻力指数(RI)。2010年1月至2012年12月,对103例单胎妊娠结局良好的孕妇(72例低风险妊娠和31例1期原发性高血压妊娠)在妊娠第1、2和3个 trimester 进行了纵向前瞻性研究。采用多元线性回归模型,使用广义最小二乘法拟合,允许误差相关和/或具有不等方差;使用了一个关于两条动脉阻抗相对差异的模型。在两组中,子宫动脉PI和RI均呈现与孕周相关的下降趋势,而髂内动脉PI和RI则升高。对有高血压和无高血压女性的血流动力学适应性进行测试的模型显示出相似趋势。无论血压情况如何,髂内动脉的阻力模式与其紧邻的盆腔分支的容量模式形成对比,提示盆腔循环中存在与妊娠相关的调节机制。