Yang Yan, Yang Yuehua, Yang Xi, Zhu Hongcheng, Guo Qing, Chen Xiaochen, Zhang Hao, Cheng Hongyan, Sun Xinchen
Department of Radiotherapy, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Tumour Biol. 2015 Jun;36(6):4079-87. doi: 10.1007/s13277-015-3496-x. Epub 2015 May 7.
Autophagy differs from apoptosis and is independent of phagocytes by the appearance of autophagosomes, autolysosomes, and complete nuclei in the cell. This process significantly contributes to the antineoplastic effects of radiation. Radiation is an important strategy in cancer treatment; however, many types of cancer show radioresistance. The effects of radiotherapy are affected by factors, including the degree of tumor tissue hypoxia, the ability to repair DNA damage, and the presence of cancer stem cells. We review the relationships among autophagy, the three factors in cancer radiation, and the possible underlying molecular mechanisms. The therapeutic implications of these relationships and mechanisms in clinical settings are also discussed.
自噬不同于凋亡，且通过细胞中自噬体、自溶酶体和完整细胞核的出现而独立于吞噬细胞。这一过程对辐射的抗肿瘤作用有显著贡献。辐射是癌症治疗中的一项重要策略；然而，许多类型的癌症表现出放射抗性。放疗效果受多种因素影响，包括肿瘤组织缺氧程度、DNA损伤修复能力以及癌症干细胞的存在。我们综述了自噬、癌症放疗中的这三个因素以及可能的潜在分子机制之间的关系。还讨论了这些关系和机制在临床环境中的治疗意义。
