Ito M, Hayashi Y, Tanabe F, Shigeta S, Kawade Y
Department of Bacteriology, Fukushima Medical College, Japan.
J Interferon Res. 1987 Aug;7(4):419-25. doi: 10.1089/jir.1987.7.419.
Human fibroblast interferon (IFN)-beta was administered in combination with the free radical-generating antiproliferative agents bleomycin (BLM), neocarzinostatin (NCS), adriamycin (ADM), and mitomycin C (MMC) to HeLa cells in culture. IFN showed a true synergistic antiproliferative activity in the presence of BLM or NCS. These effects were observed regardless of the ratio of IFN to BLM or NCS concentrations. However, the effect of IFN in the presence of ADM or MMC was additive. The possibility that IFN-beta potentiates the antiproliferative effects of these free radical-generating agents in a different manner is also discussed.
将人成纤维细胞干扰素（IFN）-β与能产生自由基的抗增殖剂博来霉素（BLM）、新制癌菌素（NCS）、阿霉素（ADM）和丝裂霉素C（MMC）联合应用于培养的HeLa细胞。在存在BLM或NCS的情况下，IFN表现出真正的协同抗增殖活性。无论IFN与BLM或NCS浓度的比例如何，均可观察到这些效应。然而，在存在ADM或MMC的情况下，IFN的作用是相加的。还讨论了IFN-β以不同方式增强这些能产生自由基的药物的抗增殖作用的可能性。
