Nascimento Déborah Victória Gomes, Alencar Darlyson Ferreira, da Silva Matheus Vinicius Barbosa, Rocha Danilo Galvão, Roncari Camila Ferreira, Jorge Roberta Jeane Bezerra, Alves Renata de Sousa, David Richard Boarato, Ferreira E Silva Wylla Tatiana, Galindo Lígia Cristina Monteiro, de Queiroz Thyago Moreira
Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Federal University of Pernambuco-UFPE, Vitória de Santo Antão 55608-680, Brazil.
Department of Morphology, School of Medicine, Federal University of Ceará-UFC, Fortaleza 60430-160, Brazil.
Biomedicines. 2024 Aug 3;12(8):1751. doi: 10.3390/biomedicines12081751.
α-Lipoic acid (LA) is an antioxidant of endogenous production, also obtained exogenously. Oxidative stress is closely associated with hypertension, which causes kidney injury and endothelial dysfunction. Here, we evaluated the cardiovascular and renal effects of LA in the two-kidney-one-clip (2K1C) hypertension model. The rats were divided into four groups: Sham surgery (Sham), the two-kidneys-one-clip (2K1C) group, and groups treated with LA for 14 days (Sham-LA and 2K1C-LA). No changes were observed in the pattern of food, water intake, and urinary volume. The left/right kidney weight LKw/RKw ratio was significantly higher in 2K1C animals. LA treatment did not reverse the increase in cardiac mass. In relation to vascular reactivity, there was an increase in the potency of phenylephrine (PHE) curve in the hypertensive animals treated with LA compared to the 2K1C group and also compared to the Sham group. Vasorelaxation induced by acetylcholine (Ach) and sodium nitroprusside (SNP) were not improved by treatment with LA. Urea and creatinine levels were not altered by the LA treatment. In conclusion, the morphological changes in the aorta and heart were not reversed; however, the treatment with LA mitigated the contraction increase induced by the 2K1C hypertension.
α-硫辛酸（LA）是一种内源性产生的抗氧化剂，也可通过外源性获取。氧化应激与高血压密切相关，高血压会导致肾损伤和内皮功能障碍。在此，我们评估了LA在二肾一夹（2K1C）高血压模型中的心血管和肾脏效应。大鼠被分为四组：假手术组（Sham）、二肾一夹（2K1C）组以及用LA治疗14天的组（Sham-LA和2K1C-LA）。在食物、水摄入量和尿量模式方面未观察到变化。2K1C动物的左/右肾重量比（LKw/RKw）显著更高。LA治疗并未逆转心脏重量的增加。关于血管反应性，与2K1C组以及假手术组相比，用LA治疗的高血压动物中去氧肾上腺素（PHE）曲线的效力有所增加。乙酰胆碱（Ach）和硝普钠（SNP）诱导的血管舒张并未因LA治疗而得到改善。LA治疗未改变尿素和肌酐水平。总之，主动脉和心脏的形态学变化未得到逆转；然而，LA治疗减轻了2K1C高血压诱导的收缩增加。
