Gyorkos Theresa W, Maheu-Giroux Mathieu, Blouin Brittany, Saavedra Lilian, Casapía Martin
Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, Royal Victoria Hospital, Montreal, QC, Canada.
Asociación Civil Selva Amazónica, Iquitos, Perú
Rev Peru Med Exp Salud Publica. 2013 Oct-Dec;30(4):601-7.
To determine the efficacy of single-dose albendazole (400 mg) for soil-transmitted helminth infections (STH) in schoolchildren living in one community of the city of Iquitos, Perú.
Within the context of a randomized controlled trial performed in a peri-urban community of limited resources located in Iquitos in the Peruvian Amazon, stool specimens were collected from Grade 5 schoolchildren in 18 schools and analysed for STH prevalence and intensity. A total of 1,193 school-age children were then dewormed with single-dose albendazole (400 mg). Of the 909 children who were found positive with at least one STH infection, a random sample of 385 was followed two weeks later when a second stool specimen was collected and analyzed.
The efficacy of albendazole was satisfactory: for Ascaris lumbricoides , with an egg reduction rate (ERR) of 99.8%; (95% CI: 99.3-100); for hookworm, with an ERR of 93.6 %; (95% CI: 88.2-96.6) and, for Trichuris trichiura, with an ERR of 72.7 %; (95% CI: 58.5-79.1).
These results are consistent with previous data published on the efficacy of albendazole and the directives of the World Health Organization. Future research should focus on improving the efficacy of the treatment strategies for Trichuris trichiura infection.
确定单剂量阿苯达唑（400毫克）对秘鲁伊基托斯市一个社区学童土壤传播蠕虫感染（STH）的疗效。
在秘鲁亚马逊地区伊基托斯市一个资源有限的城郊社区进行的一项随机对照试验中，从18所学校的五年级学童中收集粪便样本，分析STH的流行率和感染强度。然后，对总共1193名学龄儿童进行单剂量阿苯达唑（400毫克）驱虫治疗。在909名被发现至少感染一种STH的儿童中，随机抽取385名儿童，两周后收集并分析第二次粪便样本。
阿苯达唑的疗效令人满意：对蛔虫，虫卵减少率（ERR）为99.8%；（95%置信区间：99.3 - 100）；对钩虫，ERR为93.6%；（95%置信区间：88.2 - 96.6）；对鞭虫，ERR为72.7%；（95%置信区间：58.5 - 79.1）。
这些结果与先前发表的关于阿苯达唑疗效的数据以及世界卫生组织的指导方针一致。未来的研究应侧重于提高鞭虫感染治疗策略的疗效。
