Tefera Ephrem, Belay Tariku, Mekonnen Seleshi Kebede, Zeynudin Ahmed, Belachew Tefera
Department of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Dire Dawa, Ethiopia.
Department of Medical Laboratory Sciences and Pathology, College of Public Health and Medical Sciences, Jimma University, Jimma, Ethiopia.
Pan Afr Med J. 2015 Nov 18;22:252. doi: 10.11604/pamj.2015.22.252.6501. eCollection 2015.
Different brands Albendazole are commercially available and the efficacious brand/s is/are required for effective control of STHs infection. Thus, this study is aimed at determining the therapeutic efficacy of different brands of albendazole against soil transmitted helminths among school children of Jimma town.
A cross sectional survey for prevalence of geohelminths and a randomized trial for efficacy study of different brands of albendazole was conducted among students Mendera Elementary School from March 29 to April 29, 2010. Positive subjects were randomized into three treatment arms using lottery method. The collected stool samples were examined by the McMaster method. CRs were calculated using SPSS windows version 16 and ERRs were calculated using appropriate formula.
Of the 715 school children who had their stools examined, 326 were positive for STHs with a prevalence rate of 45.6%. The cure rates (CR) for A. lumbricoides, T. trichiura and Hookworm were 99.4, 59.9 and 93.7%, respectively. Similarly, the egg reduction rates (ERR) were 97, 99.9 and 99.9% respectively. A statistical significant mean STH egg count difference were observed between pre and post-intervention study (p <0.001). But no statistical significant curing effect difference were observed among the three brands used against the three STHs (p >0.05).
All the three brands of Albendazole tested regardless of the brand type were therapeutically efficacious for Ascariasis, Trichuriasis and Hookworm infections irrespective of the infection status whether it was single or multiple.
市面上有不同品牌的阿苯达唑，而有效控制土源性蠕虫感染需要有效的品牌。因此，本研究旨在确定不同品牌阿苯达唑对吉姆马镇学童土源性蠕虫的治疗效果。
2010年3月29日至4月29日，在门德拉小学的学生中进行了土源性蠕虫流行情况的横断面调查以及不同品牌阿苯达唑疗效研究的随机试验。阳性受试者通过抽签法随机分为三个治疗组。采集的粪便样本采用麦克马斯特法进行检测。使用SPSS 16.0版软件计算治愈率（CR），并使用适当公式计算虫卵减少率（ERR）。
在接受粪便检查的715名学童中，326人土源性蠕虫检测呈阳性，患病率为45.6%。蛔虫、鞭虫和钩虫的治愈率分别为99.4%、59.9%和93.7%。同样，虫卵减少率分别为97%、99.9%和99.9%。干预前后研究的土源性蠕虫平均虫卵计数差异具有统计学意义（p<0.001）。但在用于治疗三种土源性蠕虫的三个品牌之间，未观察到统计学上显著的治疗效果差异（p>0.05）。
所测试的三种品牌的阿苯达唑，无论品牌类型如何，对蛔虫病、鞭虫病和钩虫感染均具有治疗效果，无论感染情况是单一感染还是多重感染。
