肺脏发育：协调复杂器官的生成和再生。
Lung development: orchestrating the generation and regeneration of a complex organ.
机构信息
Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Development. 2014 Feb;141(3):502-13. doi: 10.1242/dev.098186.
Abstract
The respiratory system, which consists of the lungs, trachea and associated vasculature, is essential for terrestrial life. In recent years, extensive progress has been made in defining the temporal progression of lung development, and this has led to exciting discoveries, including the derivation of lung epithelium from pluripotent stem cells and the discovery of developmental pathways that are targets for new therapeutics. These discoveries have also provided new insights into the regenerative capacity of the respiratory system. This Review highlights recent advances in our understanding of lung development and regeneration, which will hopefully lead to better insights into both congenital and acquired lung diseases.
摘要
呼吸系统由肺、气管和相关血管组成，对陆地生物至关重要。近年来，人们在定义肺发育的时间进程方面取得了广泛进展，这带来了令人兴奋的发现，包括多能干细胞衍生的肺上皮细胞，以及发现了新的治疗靶点的发育途径。这些发现还为呼吸系统的再生能力提供了新的见解。这篇综述强调了我们对肺发育和再生的理解的最新进展，希望这将有助于更好地了解先天性和获得性肺病。
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