Kolomin T A, Agapova T Iu, Agniullin Ia V, Shram S I, Shadrina M I, Slominskiĭ P A, Limborskaia S A, Miasoedov I F
Zh Vyssh Nerv Deiat Im I P Pavlova. 2013 May-Jun;63(3):365-74. doi: 10.7868/s0044467713030052.
The effect of single and course administration of Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) in the dose 200 microg/kg on the rat hippocampus transcriptional profile were studied using cDNA microarray technology. It was shown that mRNA levels of 36 genes changed more than 2-fold after a single intranasal Selank administration, and 20 genes--after course administration. It should be noted that most of them encode proteins associated with the plasma membrane (including transmembrane proteins). This suggests that Selank is able to regulate ion homeostasis of hippocampal cells and thereby modulate different ion-dependent processes, which include the processes of learning and memory formation.
采用cDNA微阵列技术研究了剂量为200微克/千克的Selank（苏氨酸-赖氨酸-脯氨酸-精氨酸-脯氨酸-甘氨酸-脯氨酸）单次和疗程给药对大鼠海马转录谱的影响。结果显示，单次鼻腔内给予Selank后，36个基因的mRNA水平变化超过2倍，疗程给药后有20个基因发生变化。需要注意的是，其中大多数基因编码与质膜相关的蛋白质（包括跨膜蛋白）。这表明Selank能够调节海马细胞的离子稳态，从而调节不同的离子依赖性过程，其中包括学习和记忆形成过程。
