Lopez Dioxelis, Martinez-Luis Sergio
Center for Drug Discovery and Biodiversity, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, City of Knowledge, P.O. Box 0843-01103, Panama.
Mar Drugs. 2014 Jan 22;12(1):525-46. doi: 10.3390/md12010525.
P-glycoprotein (P-gp) is a protein belonging to the ATP-binding cassette (ABC) transporters superfamily that has clinical relevance due to its role in drug metabolism and multi-drug resistance (MDR) in several human pathogens and diseases. P-gp is a major cause of drug resistance in cancer, parasitic diseases, epilepsy and other disorders. This review article aims to summarize the research findings on the marine natural products with P-glycoprotein inhibitor properties. Natural compounds that modulate P-gp offer great possibilities for semi-synthetic modification to create new drugs and are valuable research tools to understand the function of complex ABC transporters.
P-糖蛋白（P-gp）是一种属于ATP结合盒（ABC）转运蛋白超家族的蛋白质，由于其在多种人类病原体和疾病的药物代谢及多药耐药性（MDR）中所起的作用，具有临床相关性。P-糖蛋白是癌症、寄生虫病、癫痫和其他疾病中耐药性的主要原因。这篇综述文章旨在总结具有P-糖蛋白抑制剂特性的海洋天然产物的研究结果。调节P-糖蛋白的天然化合物为半合成修饰以开发新药提供了巨大可能性，并且是了解复杂ABC转运蛋白功能的有价值的研究工具。
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