Seymour R A, Smith D G, Turnbull D N
J Clin Periodontol. 1985 Jul;12(6):413-9. doi: 10.1111/j.1600-051x.1985.tb01377.x.
The periodontal health of 30 adult epileptic patients treated with either sodium valproate or phenytoin was compared with a control group (n = 15) of otherwise healthy patients. The 3 groups were matched for age and sex. Patients on phenytoin therapy showed significantly higher plaque scores (P less than 0.05), gingival index (P less than 0.05) and pocketing (P less than 0.05) than patients in the control group. The % of gingival hyperplasia was significantly higher (P less than 0.05) in the phenytoin-treated patients than those on sodium valproate or in the control group. However, patients on phenytoin therapy had significantly less bone loss than those on sodium valproate (P less than 0.05) or in the control group (P less than 0.01). No significant differences were observed between the sodium valproate group and the control group on any of the parameters assessed. The results from this study would suggest that sodium valproate has no unwanted effects on periodontal health and may be considered a safe alternative, regarding the periodontal aspects, to phenytoin for the treatment of adult onset epilepsy.
将30例接受丙戊酸钠或苯妥英治疗的成年癫痫患者的牙周健康状况与15例健康对照患者进行比较。三组在年龄和性别上相匹配。接受苯妥英治疗的患者的菌斑评分（P<0.05）、牙龈指数（P<0.05）和牙周袋深度（P<0.05）显著高于对照组患者。接受苯妥英治疗的患者牙龈增生百分比显著高于接受丙戊酸钠治疗的患者或对照组（P<0.05）。然而，接受苯妥英治疗的患者的骨丢失显著少于接受丙戊酸钠治疗的患者（P<0.05）或对照组（P<0.01）。在评估的任何参数上，丙戊酸钠组和对照组之间均未观察到显著差异。本研究结果表明，丙戊酸钠对牙周健康没有不良影响，就牙周方面而言，对于成人癫痫的治疗，丙戊酸钠可能是苯妥英的安全替代品。
