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肉豆蔻中毒:对伊利诺伊州中毒控制中心2001年至2011年十年经验的回顾性研究

Nutmeg poisonings: a retrospective review of 10 years experience from the Illinois Poison Center, 2001-2011.

作者信息

Ehrenpreis Jamie E, DesLauriers Carol, Lank Patrick, Armstrong P Keelan, Leikin Jerrold B

机构信息

Rosalind Franklin University of Medicine and Science, 8918 N Keeler Ave., Skokie, IL, 60076, USA,

出版信息

J Med Toxicol. 2014 Jun;10(2):148-51. doi: 10.1007/s13181-013-0379-7.

Abstract

Nutmeg is a commonly consumed spice. The toxic effects of nutmeg have been purported to be due mainly to myristicin oil. Prior poison center series of nutmeg exposures show very few unintentional exposures of nutmeg to children younger than 13. Case series from these centers did not record drug exposures combined with nutmeg. This study is a review of Illinois Poison Center (IPC) data regarding nutmeg exposures from January of 2001 to December 2011. The goal of this study was to compare the Illinois data to the literature as well as look for current trends in nutmeg poisonings. The data were extracted using the code for hallucinogenic plants in the IPC database, and poisonings unrelated to nutmeg exposure were eliminated. Medical outcomes were noted as recorded. Thirty-two cases of nutmeg ingestion were reported. Of the 17 (53.1 %) unintentional exposures, 10 subjects (58.8 %) were under the age of 13. Four of the exposures in children under the age of 13 were ocular exposures. Fifteen exposures (46.9 %) were intentional exposures. Of these intentional exposures, five (33.3 %) were recorded to have combined drug intoxication. All of these were between the ages of 15 and 20. One patient with polypharmaceutical exposure required ventilatory support in the hospital. Our study shows an unexpected percentage of unintentional exposures in juveniles under the age of 13, out of the total exposures to nutmeg. Mixing of nutmeg with other drugs was seen and required more intervention in adolescents. More education about these two factors, i.e., nutmeg exposures as intentional polypharmacy in adolescents and unintentional exposures in young children, is advised.

摘要

肉豆蔻是一种常见的食用香料。肉豆蔻的毒性作用据称主要归因于肉豆蔻醚油。此前关于肉豆蔻暴露的中毒控制中心系列报告显示,13岁以下儿童极少有因意外接触肉豆蔻而中毒的情况。这些中心的病例系列未记录与肉豆蔻同时发生的药物暴露情况。本研究回顾了伊利诺伊州中毒控制中心(IPC)2001年1月至2011年12月期间有关肉豆蔻暴露的数据。本研究的目的是将伊利诺伊州的数据与文献进行比较,并探寻肉豆蔻中毒的当前趋势。数据是使用IPC数据库中致幻植物的代码提取的,与肉豆蔻暴露无关的中毒情况被排除。记录了医疗结果。报告了32例肉豆蔻摄入病例。在17例(53.1%)意外暴露病例中,10名受试者(58.8%)年龄在13岁以下。13岁以下儿童的暴露中有4例是眼部暴露。15例(46.9%)是故意暴露。在这些故意暴露病例中,有5例(33.3%)记录有合并药物中毒。所有这些病例年龄都在15至20岁之间。一名多药暴露患者在医院需要呼吸支持。我们的研究表明,在肉豆蔻总暴露病例中,13岁以下青少年意外暴露的比例出人意料。发现肉豆蔻与其他药物混合使用的情况,且在青少年中需要更多干预。建议针对这两个因素,即青少年故意多药滥用肉豆蔻暴露和幼儿意外暴露,开展更多教育。

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