乙醇喂养对大鼠胰腺中胶原蛋白合成及降解酶的影响。

Effects of ethanol feeding on collagen synthesizing and degrading enzymes in rat pancreas.

作者信息

Yamada M, Murawaki Y, Hirayama C

机构信息

Second Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.

出版信息

Biochem Pharmacol. 1987 Oct 15;36(20):3361-4. doi: 10.1016/0006-2952(87)90311-x.

DOI:10.1016/0006-2952(87)90311-x

PMID:2445347

Abstract

Collagen metabolism in the pancreas was investigated in male Wistar strain rats after 7 weeks of ethanol feeding. Compared with control rats, the ethanol-fed rats had a normal hydroxyproline content in the pancreas. However, prolyl hydroxylase activity and collagenolytic cathepsin activity were increased, though collagenase activity did not change. Both prolyl hydroxylase activity and collagenolytic cathepsin activity were inversely correlated with amylase activities. These findings were also confirmed in ethanol-pyrazole treated rats. These results suggest that the ethanol-induced pancreatic injury, even at an early stage, accelerates the collagen metabolism in the pancreas.

摘要

在给雄性Wistar品系大鼠喂食乙醇7周后，对其胰腺中的胶原蛋白代谢进行了研究。与对照大鼠相比，喂食乙醇的大鼠胰腺中的羟脯氨酸含量正常。然而，脯氨酰羟化酶活性和胶原分解组织蛋白酶活性增加，尽管胶原酶活性没有变化。脯氨酰羟化酶活性和胶原分解组织蛋白酶活性均与淀粉酶活性呈负相关。在乙醇-吡唑处理的大鼠中也证实了这些发现。这些结果表明，即使在早期阶段，乙醇诱导的胰腺损伤也会加速胰腺中的胶原蛋白代谢。