肝脏胶原代谢：酒精摄入对大鼠和狒狒的影响。
Hepatic collagen metabolism: effect of alcohol consumption in rats and baboons.
作者信息
Feinman L, Lieber C S
出版信息
Science. 1972 May 19;176(4036):795. doi: 10.1126/science.176.4036.795.
PMID:4337988
Abstract
Long-term ethanol feeding causes collagen accumulation in livers of rats and baboons. Activity of collagen proline hydroxylase in the liver is also stimulated, and incorporation of proline into collagen hydroxyproline in rat liver slices is significantly enhanced, a result indicating that increased synthesis is responsible, in part, for the collagen accumulation.
摘要
长期喂食乙醇会导致大鼠和狒狒肝脏中胶原蛋白积累。肝脏中胶原蛋白脯氨酸羟化酶的活性也会受到刺激，并且脯氨酸掺入大鼠肝脏切片中胶原蛋白羟脯氨酸的量显著增加，这一结果表明合成增加部分导致了胶原蛋白的积累。
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