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一锅法通过连续自由基/离子反应将两个一碳组分并入烷基溴中合成氰醇衍生物。

One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions.

机构信息

Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.

出版信息

Beilstein J Org Chem. 2014 Jan 14;10:150-4. doi: 10.3762/bjoc.10.12.

DOI:10.3762/bjoc.10.12
PMID:24454568
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3896227/
Abstract

The consecutive radical/ionic reaction consisting of radical formylation of alkyl bromides and nucleophilic addition of a cyanide ion was investigated, which gave moderate to good yields of cyanohydrin derivatives in one-pot.

摘要

研究了由烷基溴的自由基甲酰化和氰离子的亲核加成组成的连续自由基/离子反应，一锅法得到了中等至良好收率的氰醇衍生物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e650/3896227/46e646961176/Beilstein_J_Org_Chem-10-150-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e650/3896227/397582ed7477/Beilstein_J_Org_Chem-10-150-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e650/3896227/46e646961176/Beilstein_J_Org_Chem-10-150-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e650/3896227/397582ed7477/Beilstein_J_Org_Chem-10-150-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e650/3896227/46e646961176/Beilstein_J_Org_Chem-10-150-g003.jpg

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