Lawal Ahmed O, Adisa Akinyele O, Kolude Bamidele, Adeyemi Bukola F, Olajide Mofoluwaso A
FMCDS, Lecturer/Consultant. Department of Oral Pathology, College of Medicine, University of Ibadan, Nigeria.
FWACS, Lecturer/Consultant. Department of Oral Pathology, College of Medicine, University of Ibadan, Nigeria.
J Clin Exp Dent. 2013 Dec 1;5(5):e218-22. doi: 10.4317/jced.51143.
Salivary gland tumours (SGTs) are a group of heterogeneous lesions with complex clinico-pathological characteristics and distinct biological behaviours. Previous studies have reported geographic variations in site distribution, incidence and histological types of SGTs. The aim of this study was to describe the demography of SGTs seen at a tertiary health centre and compare findings with previous studies.
Data on SGTs from archives of the Department of Oral Pathology and the Department of Pathology, University College Hospital Ibadan were retrieved. Information about histological types, age, sex and location were analyzed using SPSS for Window (version 20.0; SPSS Inc. Chicago, IL). Reactive and tumor-like lesions such as sialometaplasia, benign lymphoepithelial lesion, lymphoepithelial cyst, mucocele, mucous extravasation phenomenon, ranula, and sialosis were excluded from the study.
413 SGTs consisting of 221 (53.5%) malignant and 192 (46.5%) benign lesions were seen. SGTs occurred more in females (50.6%) than males (49.4%) with a mean age of 43.7 (±16.9) years and peak age in the fifth decade of life. The parotid with 171 (41.4%) cases was the commonest site, followed by palate with 89 (21.5%) cases, while only 7(1.7%) cases were seen in sublingual gland. Pleomorphic adenoma with 169 (40.9%) was the most frequent SGT followed by adenoid cystic carcinoma with 93 (22.5%) cases which also was the most frequent malignant SGT while only 3 (0.7%) cases of Warthin's tumour were seen.
This report is one of few that showed a higher occurrence of malignant SGTs compared to their benign counterparts. The findings were essentially similar to findings in Africa but showed SGTs to be more common in females. The reason(s) for high occurrence of malignant SGTs in minor salivary glands and the rarity of Warthins tumour in this study and other African series compared to those from America needs further investigation. Key words:Salivary gland tumours, parotid gland, pleomorphic adenoma, adenoid cystic carcinoma, warthin's tumour.
唾液腺肿瘤（SGTs）是一组具有复杂临床病理特征和独特生物学行为的异质性病变。既往研究报道了SGTs在部位分布、发病率和组织学类型上的地理差异。本研究的目的是描述在一家三级医疗中心所见SGTs的人口统计学特征，并将结果与既往研究进行比较。
检索了伊巴丹大学学院医院口腔病理学系和病理学系档案中的SGTs数据。使用SPSS for Window（版本20.0；SPSS公司，伊利诺伊州芝加哥）分析有关组织学类型、年龄、性别和部位的信息。本研究排除了诸如涎腺化生、良性淋巴上皮病变、淋巴上皮囊肿、黏液囊肿、黏液外渗现象、舌下囊肿和涎腺肿大等反应性和肿瘤样病变。
共观察到413例SGTs，其中恶性病变221例（53.5%），良性病变192例（46.5%）。SGTs在女性中的发生率（50.6%）高于男性（49.4%），平均年龄为43.7（±16.9）岁，发病高峰年龄在生命的第五个十年。腮腺是最常见的部位，有171例（41.4%），其次是腭部，有89例（21.5%），而舌下腺仅见7例（1.7%）。多形性腺瘤169例（40.9%）是最常见的SGT，其次是腺样囊性癌93例（22.5%），腺样囊性癌也是最常见的恶性SGT，而沃辛瘤仅见3例（0.7%）。
本报告是少数显示恶性SGTs发生率高于良性SGTs的报告之一。研究结果与非洲的研究结果基本相似，但显示SGTs在女性中更为常见。与美国的研究相比，本研究及其他非洲系列研究中涎腺小涎腺恶性SGTs发生率高及沃辛瘤罕见的原因需要进一步研究。关键词：唾液腺肿瘤、腮腺、多形性腺瘤、腺样囊性癌、沃辛瘤
