Korpetinou Angeliki, Skandalis Spyros S, Labropoulou Vassiliki T, Smirlaki Gianna, Noulas Argyrios, Karamanos Nikos K, Theocharis Achilleas D
Laboratory of Biochemistry, Department of Chemistry, University of Patras , Patras , Greece.
Division of Hematology, University Hospital of Patras , Patras , Greece.
Front Oncol. 2014 Jan 13;3:327. doi: 10.3389/fonc.2013.00327.
Serglycin has been initially characterized as an intracellular proteoglycan expressed by hematopoietic cells. All inflammatory cells highly synthesize serglycin and store it in granules, where it interacts with numerous inflammatory mediators, such as proteases, chemokines, cytokines, and growth factors. Serglycin is implicated in their storage into the granules and their protection since they are secreted as complexes and delivered to their targets after secretion. During the last decade, numerous studies have demonstrated that serglycin is also synthesized by various non-hematopoietic cell types. It has been shown that serglycin is highly expressed by tumor cells and promotes their aggressive phenotype and confers resistance against drugs and complement system attack. Apart from its direct beneficial role to tumor cells, serglycin may promote the inflammatory process in the tumor cell microenvironment thus enhancing tumor development. In the present review, we discuss the role of serglycin in inflammation and tumor progression.
丝甘蛋白聚糖最初被表征为造血细胞表达的一种细胞内蛋白聚糖。所有炎症细胞都能大量合成丝甘蛋白聚糖并将其储存于颗粒中，在颗粒中它与多种炎症介质相互作用，如蛋白酶、趋化因子、细胞因子和生长因子。丝甘蛋白聚糖参与这些介质在颗粒中的储存及其保护过程，因为它们以复合物形式分泌，并在分泌后传递至其靶标。在过去十年中，大量研究表明各种非造血细胞类型也能合成丝甘蛋白聚糖。已显示丝甘蛋白聚糖在肿瘤细胞中高度表达，促进其侵袭性表型，并赋予对药物和补体系统攻击的抗性。除了对肿瘤细胞有直接的有益作用外，丝甘蛋白聚糖可能促进肿瘤细胞微环境中的炎症过程，从而增强肿瘤发展。在本综述中，我们讨论丝甘蛋白聚糖在炎症和肿瘤进展中的作用。
