Department of Medicinal Chemistry, University of Kansas , Lawrence, Kansas 66045, United States.
J Nat Prod. 2013 Nov 22;76(11):2040-6. doi: 10.1021/np400296s. Epub 2013 Oct 23.
Methanol solutions of the main withanolides (6-8) naturally present in Physalis longifolia yielded five artificial withanolides (1-5), including three new compounds (1-3). Withanolides 1 and 2 were identified as intramolecular Michael addition derivatives, while withanolides 3-5 were the result of intermolecular Michael addition. A comprehensive literature investigation was conducted to identify potential withanolide Michael addition artifacts isolated from Solanaceous species to date.
甲醇溶液中的主要醉茄内酯（6-8）天然存在于长梗酸模中，生成了五种人工醉茄内酯（1-5），包括三种新化合物（1-3）。化合物 1 和 2 被鉴定为分子内迈克尔加成衍生物，而化合物 3-5 则是分子间迈克尔加成的结果。进行了全面的文献调查，以确定迄今为止从茄科物种中分离出的潜在醉茄内酯迈克尔加成人工产物。
