Montoliu Ivan, Scherer Max, Beguelin Fiona, DaSilva Laeticia, Mari Daniela, Salvioli Stefano, Martin Francois-Pierre J, Capri Miriam, Bucci Laura, Ostan Rita, Garagnani Paolo, Monti Daniela, Biagi Elena, Brigidi Patrizia, Kussmann Martin, Rezzi Serge, Franceschi Claudio, Collino Sebastiano
NESTEC SA, Nestlé Research Center, Vers-chez-les-Blanc, CH-1000 Lausanne 26, Switzerland.
Aging (Albany NY). 2014 Jan;6(1):9-25. doi: 10.18632/aging.100630.
As centenarians well represent the model of healthy aging, there are many important implications in revealing the underlying molecular mechanisms behind such successful aging. By combining NMR metabonomics and shot-gun lipidomics in serum we analyzed metabolome and lipidome composition of a group of centenarians with respect to elderly individuals. Specifically, NMR metabonomics profiling of serum revealed that centenarians are characterized by a metabolic phenotype distinct from that of elderly subjects, in particular regarding amino acids and lipid species. Shot- gun lipidomics approach displays unique changes in lipids biosynthesis in centenarians, with 41 differently abundant lipid species with respect to elderly subjects. These findings reveal phospho/sphingolipids as putative markers and biological modulators of healthy aging, in humans. Considering the particular actions of these metabolites, these data are suggestive of a better counteractive antioxidant capacity and a well-developed membrane lipid remodelling process in the healthy aging phenotype.
由于百岁老人很好地代表了健康衰老的模式，揭示这种成功衰老背后的潜在分子机制具有许多重要意义。通过结合血清中的核磁共振代谢组学和鸟枪法脂质组学，我们分析了一组百岁老人相对于老年人的代谢组和脂质组组成。具体而言，血清的核磁共振代谢组学分析表明，百岁老人具有与老年受试者不同的代谢表型，特别是在氨基酸和脂质种类方面。鸟枪法脂质组学方法显示，百岁老人的脂质生物合成存在独特变化，相对于老年受试者有41种脂质种类的丰度不同。这些发现揭示了磷酸/鞘脂类物质作为人类健康衰老的假定标志物和生物调节剂。考虑到这些代谢物的特殊作用，这些数据表明在健康衰老表型中具有更好的抗氧化能力和完善的膜脂质重塑过程。
