Zarezadeh Meysam, Mahmoudinezhad Mahsa, Faghfouri Amir Hossein, Radkhah Nima, Jamali Mehrdad, Jamilian Parsa, Ghoreyshi Zohreh, Ostadrahimi Alireza
Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Health Promot Perspect. 2025 May 6;15(1):23-36. doi: 10.34172/hpp.025.42914. eCollection 2025 May.
The lipidome, as a subset of metabolomics, can undergo significant variations due to several factors, including the aging process. Therefore, this study aims to summarize the relationship between aging and alterations in plasma phospholipids.
A comprehensive search was conducted in MEDLINE (PubMed), Scopus, Embase, Web of Science, and Google Scholar databases up to September 2023. The PRISMA guidelines were adhered to throughout all stages of the review process. Cross-sectional and case-control studies that investigated the relationship between aging and phosphatidylcholine (PC), lysophosphatidylcholine (LPC), sphingomyelins (SM), ceramides, phosphatidylethanolamines (PE), and phosphatidylinositol (PI) were included.
A total of 8486 studies were identified, of which 32 met the predefined inclusion criteria. The systematic review included data from 70,499 participants. The findings revealed that four studies reported a positive association between PCs and aging in both sexes, while one study reported an inverse relationship. Additionally, two studies found that PCs were positively associated with aging in men and negatively associated in women. Furthermore, four studies indicated a negative association between PC metabolites and the aging process. With regard to LPCs, two studies demonstrated a positive correlation, and two studies showed an inverse correlation with aging in both sexes. For SMs, five studies reported a positive association, whereas two studies identified an inverse association with aging trends. Similarly, five studies reported a positive correlation between PE levels and aging, while two studies showed a negative correlation.
Phospholipids play a critical role in the aging process, aging-related diseases, and the regulation of lifespan. A reduction in the levels of PCs and LPCs has been identified as a characteristic feature of aging.
脂质组作为代谢组学的一个子集，会因包括衰老过程在内的多种因素而发生显著变化。因此，本研究旨在总结衰老与血浆磷脂变化之间的关系。
截至2023年9月，在MEDLINE（PubMed）、Scopus、Embase、Web of Science和谷歌学术数据库中进行了全面检索。在综述过程的所有阶段均遵循PRISMA指南。纳入了调查衰老与磷脂酰胆碱（PC）、溶血磷脂酰胆碱（LPC）、鞘磷脂（SM）、神经酰胺、磷脂酰乙醇胺（PE）和磷脂酰肌醇（PI）之间关系的横断面研究和病例对照研究。
共识别出8486项研究，其中32项符合预定义的纳入标准。该系统综述纳入了来自70499名参与者的数据。研究结果显示，四项研究报告PCs与两性衰老呈正相关，而一项研究报告呈负相关。此外两项研究发现，PCs与男性衰老呈正相关，与女性衰老呈负相关。此外，四项研究表明PC代谢物与衰老过程呈负相关。关于LPCs，两项研究表明其与两性衰老呈正相关，两项研究表明呈负相关。对于SMs，五项研究报告呈正相关，而两项研究发现与衰老趋势呈负相关。同样，五项研究报告PE水平与衰老呈正相关，而两项研究显示呈负相关。
磷脂在衰老过程、衰老相关疾病和寿命调节中起关键作用。PCs和LPCs水平降低已被确定为衰老的一个特征。
