鉴定人类白细胞共同抗原上2H4表位表达所需的序列。
Identification of the sequence required for expression of the 2H4 epitope on the human leukocyte common antigens.
作者信息
Streuli M, Matsuyama T, Morimoto C, Schlossman S F, Saito H
机构信息
Division of Tumor Immunology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115.
出版信息
J Exp Med. 1987 Nov 1;166(5):1567-72. doi: 10.1084/jem.166.5.1567.
Abstract
The anti-2H4 antibody, which subdivides the T4+ population of human T lymphocytes into T4+, 2H4+ suppressor-inducer cells and T4+, 2H4- helper cells, recognizes an epitope on a subset of the human leukocyte common antigens (LCAs). LCAs are a family of cell surface glycoproteins generated from a single gene by the differential usage of three exons near the NH2-terminus. Using cDNA clones corresponding to four of the different forms of LCA molecules, extracellular domains of the LCA molecules were synthesized in vitro. Immunoprecipitation of these molecules with the anti-2H4 antibody demonstrated that exon A is required for the expression of the 2H4 epitope.
摘要
抗2H4抗体可将人T淋巴细胞的T4 +群体细分为T4 +、2H4 +抑制诱导细胞和T4 +、2H4 -辅助细胞，该抗体识别人类白细胞共同抗原（LCA）子集上的一个表位。LCA是通过在NH2末端附近对三个外显子的差异使用而从单个基因产生的细胞表面糖蛋白家族。利用与四种不同形式的LCA分子相对应的cDNA克隆，在体外合成了LCA分子的胞外结构域。用抗2H4抗体对这些分子进行免疫沉淀表明，外显子A是2H4表位表达所必需的。
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