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蝶豆（豆科）叶对实验性动物糖尿病诱导的认知衰退的神经保护和益智活性

Neuroprotective and nootropic activity of Clitorea ternatea Linn.(Fabaceae) leaves on diabetes induced cognitive decline in experimental animals.

作者信息

Talpate Karuna A, Bhosale Uma A, Zambare Mandar R, Somani Rahul S

机构信息

Department of Pharmacology, Sinhgad College of Pharmacy, Vadgaon, Pune, Maharashtra, India.

Department of Pharmacology, Smt. Kashibai Navale Medical College and General Hospital, Narhe, Pune, Maharashtra, India.

出版信息

J Pharm Bioallied Sci. 2014 Jan;6(1):48-55. doi: 10.4103/0975-7406.124317.

DOI:10.4103/0975-7406.124317
PMID:24459404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3895294/
Abstract

PURPOSE

Ethanol extract of Clitorea ternatea (EECT) was evaluated in diabetes-induced cognitive decline rat model for its nootropic and neuroprotective activity.

MATERIALS AND METHODS

Effect on spatial working memory, spatial reference memory and spatial working-reference memory was evaluated by Y maze, Morris water maze and Radial arm maze respectively. Neuroprotective effects of EECT was studied by assaying acetylcholinesterase, lipid peroxide, superoxide dismutase (SOD), total nitric oxide (NO), catalase (CAT) and glutathione (GSH) levels in the brain of diabetic rats.

RESULTS

The EECT (200 and 400 mg/kg) was found to cause significant increase in spatial working memory (P < 0.05), spatial reference memory (P < 0.001) and spatial working-reference (P < 0.001) in retention trials on Y maze, Morris water maze and Radial arm maze respectively. Whereas significant decrease in acetylcholinesterase activity (P < 0.05), lipid peroxide (P < 0.001), total NO (P < 0.001) and significant increase in SOD, CAT and GSH levels was observed in animals treated with EECT (200 and 400 mg/kg) compared to diabetic control group.

CONCLUSIONS

The present data indicates that Clitorea ternatea tenders protection against diabetes induced cognitive decline and merits the need for further studies to elucidate its mode of action.

摘要

目的

在糖尿病诱导的认知衰退大鼠模型中评估蝶豆乙醇提取物（EECT）的促智和神经保护活性。

材料与方法

分别通过Y迷宫、莫里斯水迷宫和放射状臂迷宫评估对空间工作记忆、空间参考记忆和空间工作-参考记忆的影响。通过测定糖尿病大鼠脑中乙酰胆碱酯酶、脂质过氧化物、超氧化物歧化酶（SOD）、总一氧化氮（NO）、过氧化氢酶（CAT）和谷胱甘肽（GSH）水平来研究EECT的神经保护作用。

结果

发现EECT（200和400mg/kg）分别在Y迷宫、莫里斯水迷宫和放射状臂迷宫的保持试验中，能显著提高空间工作记忆（P<0.05）、空间参考记忆（P<0.001）和空间工作-参考记忆（P<0.001）。与糖尿病对照组相比，接受EECT（200和400mg/kg）治疗的动物乙酰胆碱酯酶活性显著降低（P<0.05）、脂质过氧化物（P<0.001）、总NO（P<0.001）显著降低，而SOD、CAT和GSH水平显著升高。

结论

目前的数据表明，蝶豆对糖尿病诱导的认知衰退具有保护作用，值得进一步研究以阐明其作用方式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71c4/3895294/8012560f2c4a/JPBS-6-48-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71c4/3895294/8012560f2c4a/JPBS-6-48-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71c4/3895294/8012560f2c4a/JPBS-6-48-g001.jpg

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