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褐黄病患者的全髋关节置换术：一项技术技巧。

Total hip replacement for an ochronotic patient: A technical trick.

作者信息

Cebesoy Oguz, Isik Mustafa, Subasi Mehmet, Kaya Abbas, Bilgin Fethi, Kaya Oğuz

机构信息

Department of Orthopedics and Traumatology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey.

出版信息

Am J Case Rep. 2014 Jan 17;15:27-30. doi: 10.12659/AJCR.890008. eCollection 2014.

DOI:10.12659/AJCR.890008
PMID:24459540
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3899173/
Abstract

PATIENT

Male, 46 FINAL DIAGNOSIS: Akkaptonuria Symptoms: Hip pain Medication: - Clinical Procedure: Total hip replacement Specialty: Orthopedics and Traumatology.

OBJECTIVE

Unusual or unexpected effect of treatment.

BACKGROUND

Ochronosis is an inherited metabolic disease in which there is an accumulation of excessive amounts of homogentisic acid in the connective tissue. As the disease progresses, the chronic inflammation in the damaged tissue can cause degeneration and osteoarthritis. There is no specific treatment for ochronosis because it is a rare disease and arthroplasty is seldom performed.

CASE REPORT

We report the case of a 46-year-old male patient with ochronosis, who underwent an arthroplasty of the right hip due to osteoarthritis. The problems encountered during surgery are reported and discussed.

CONCLUSIONS

Arthroplasty is a highly effective procedure for ochronotic patients. Particular attention to the surgical step is highly advised.

摘要

患者

男性，46岁 最终诊断：褐黄病 症状：髋关节疼痛 用药：- 临床手术：全髋关节置换术 专科：骨科与创伤科。

目的

治疗的异常或意外效果。

背景

褐黄病是一种遗传性代谢疾病，其中结缔组织中会积累过量的尿黑酸。随着疾病进展，受损组织中的慢性炎症可导致退变和骨关节炎。由于褐黄病是一种罕见疾病且很少进行关节成形术，因此没有针对褐黄病的特异性治疗方法。

病例报告

我们报告一例46岁患有褐黄病的男性患者，该患者因骨关节炎接受了右髋关节成形术。报告并讨论了手术中遇到的问题。

结论

关节成形术对褐黄病患者是一种非常有效的手术。强烈建议特别关注手术步骤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51c0/3899173/a73d7ca9b028/amjcaserep-15-27-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51c0/3899173/47913fcf32a8/amjcaserep-15-27-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51c0/3899173/519b5bfabc9e/amjcaserep-15-27-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51c0/3899173/ac549e4c1cb4/amjcaserep-15-27-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51c0/3899173/a73d7ca9b028/amjcaserep-15-27-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51c0/3899173/47913fcf32a8/amjcaserep-15-27-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51c0/3899173/519b5bfabc9e/amjcaserep-15-27-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51c0/3899173/ac549e4c1cb4/amjcaserep-15-27-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51c0/3899173/a73d7ca9b028/amjcaserep-15-27-g004.jpg

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High frequency of alkaptonuria in Slovakia: evidence for the appearance of multiple mutations in HGO involving different mutational hot spots.斯洛伐克黑尿症的高发病率：HGO中涉及不同突变热点的多个突变出现的证据。
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