Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Korea.
Clin Mol Hepatol. 2013 Dec;19(4):376-81. doi: 10.3350/cmh.2013.19.4.376. Epub 2013 Dec 28.
BACKGROUND/AIMS: To identify the predicting factors of present hepatitis C virus (HCV) infection among patients with positivity for antibodies to HCV (anti-HCV).
We analyzed patients who showed positive enzyme immunoassay (EIA) results and performed an HCV RNA test as a confirmatory test at Kyung Hee University Hospital at Gangdong from June 2006 to July 2012. The features distinguishing the groups with positive and negative HCV RNA results were reviewed.
In total, 490 patients were included. The results of the HCV RNA test were positive and negative in 228 and 262 patients, respectively. The index value of anti-HCV, mean age, platelet counts, total bilirubin, prothrombin time international normalized ratio, albumin and alanine transaminase (ALT) levels differed significantly between the two groups. On multivariable analysis, an index value of anti-HCV >10 [odds ratio (OR)=397.27, P<0.001), ALT >40 IU/L (OR=3.64, P=0.001), and albumin <3.8 g/dL (OR=2.66, P=0.014) were related to present HCV infection.
Although EIA is not a quantitative test, considering the anti-HCV titer with ALT and albumin levels may be helpful in predicting present of HCV infection.
背景/目的：确定抗 HCV 抗体阳性患者中当前 HCV 感染的预测因素。
我们分析了 2006 年 6 月至 2012 年 7 月在庆熙大学东光医院进行酶免疫分析（EIA）结果阳性并进行 HCV RNA 检测作为确认试验的患者。回顾了 HCV RNA 结果阳性和阴性组之间的特征差异。
共纳入 490 例患者。HCV RNA 检测结果阳性和阴性的患者分别为 228 例和 262 例。两组抗 HCV 指数值、平均年龄、血小板计数、总胆红素、凝血酶原时间国际标准化比值、白蛋白和丙氨酸转氨酶（ALT）水平差异有统计学意义。多变量分析显示，抗 HCV 指数值>10[比值比（OR）=397.27，P<0.001）、ALT>40IU/L（OR=3.64，P=0.001）和白蛋白<3.8g/dL（OR=2.66，P=0.014）与当前 HCV 感染相关。
尽管 EIA 不是定量检测，但考虑到抗 HCV 滴度与 ALT 和白蛋白水平相结合，可能有助于预测当前 HCV 感染。
