Parthun Mark R
Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Biochim Biophys Acta. 2012 Mar-Apr;1819(3-4):256-63. doi: 10.1016/j.bbagrm.2011.07.006. Epub 2011 Jul 18.
Histone acetyltransferase 1 (HAT1) is an enzyme that is likely to be responsible for the acetylation that occurs on lysines 5 and 12 of the NH2-terminal tail of newly synthesized histone H4. Initial studies suggested that, despite its evolutionary conservation, this modification of new histone H4 played only a minor role in chromatin assembly. However, a number of recent studies have brought into focus the important role of both this modification and HAT1 in histone dynamics. Surprisingly, the function of HAT1 in chromatin assembly may extend beyond just its catalytic activity to include its role as a major histone binding protein. These results are incorporated into a model for the function of HAT1 in histone deposition and chromatin assembly. This article is part of a Special issue entitled: Histone chaperones and Chromatin assembly.
组蛋白乙酰转移酶1（HAT1）是一种酶，可能负责新乙酰质作用于新合成的组蛋白H4氨基末端尾巴上赖氨酸5和12的乙酰化反应。初步研究表明，尽管这种修饰在进化上具有保守性，但新合成的组蛋白H4的这种修饰在染色质组装中仅起次要作用。然而，最近的一些研究已将这种修饰和HAT1在组蛋白动态变化中的重要作用聚焦起来。令人惊讶的是，HAT1在染色质组装中的功能可能不仅限于其催化活性，还包括其作为主要组蛋白结合蛋白的作用。这些结果被纳入到一个关于HAT1在组蛋白沉积和染色质组装中功能的模型中。本文是名为“组蛋白伴侣与染色质组装”特刊的一部分。
