State Key Laboratory of Chemical Engineering, East China University of Science and Technology , Shanghai 200237, People's Republic of China.
Langmuir. 2014 Feb 18;30(6):1636-42. doi: 10.1021/la4045623. Epub 2014 Feb 3.
Biocompatible nanocomposite hydrogels (NC gels) consisting of poly(acrylic acid) (PAA) and nanosized clay (Laponite) were successfully synthesized by in situ free-radical polymerization of acrylic acid (AA) in aqueous solutions of Laponite. The obtained NC gels were uniform and transparent. Their viscosity, storage modulus G', and loss modulus G″ increased significantly upon increasing the content of Laponite and the dose of AA, while exhibiting a maximum with increasing the neutralization degree of AA. They showed tunable adhesion by changing the dose of Laponite and monomer as well as the neutralization degree of AA, as determined by 180° peel strength measurement. The maximal adhesion was shown when reaching a balance between cohesion and fluidity. A homemade Johnson-Kendall-Roberts (JKR) instrument was employed to study the surface adhesion behavior of the NC gels. The combination of peel strength, rheology, and JKR measurements offers the opportunity of insight into the mechanism of adhesion of hydrogels. The NC gels with tunable adhesion should be ideal candidates for dental adhesive, wound dressing, and tissue engineering.
由聚（丙烯酸）（PAA）和纳米级粘土（Laponite）组成的生物相容性纳米复合水凝胶（NC 凝胶）通过在 Laponite 的水溶液中进行丙烯酸（AA）的原位自由基聚合成功合成。所得 NC 凝胶均匀透明。它们的粘度、储能模量 G'和损耗模量 G"随着 Laponite 含量和 AA 剂量的增加而显著增加，而随着 AA 中和度的增加则呈现出最大值。通过改变 Laponite 和单体的剂量以及 AA 的中和度，可以通过 180°剥离强度测量来调节粘附力。当达到内聚和流动性之间的平衡时，显示出最大的粘附力。使用自制的 Johnson-Kendall-Roberts（JKR）仪器研究了 NC 凝胶的表面粘附行为。剥离强度、流变学和 JKR 测量的结合为研究水凝胶粘附机制提供了机会。具有可调粘附力的 NC 凝胶应该是牙科胶粘剂、伤口敷料和组织工程的理想候选材料。
