Zhu Wen-Jiang, Huang Chu-Ying, Li Chuan, Peng Wei, Wen Tian-Fu, Yan Lv-Nan, Li Bo, Wang Wen-Tao, Xu Ming-Qing, Yang Jia-Yin, Jiang Li
Liver Transplantation Center, Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu, China E-mail :
Asian Pac J Cancer Prev. 2013;14(12):7101-6. doi: 10.7314/apjcp.2013.14.12.7101.
The prognosis of patients with hepatocellular carcinoma (HCC) after curative resection varies greatly. Few studies had investigated the risk factors for early recurrence (recurrence-free time ≤ 1 year) of hepatitis B virus (HBV)-related HCCs meeting Milan criteria.
A retrospective analysis was performed on the 224 patients with HCC meeting Milan criteria who underwent curative liver resection in our center between February 2007 and March 2012. The overall survival (OS) rate, recurrence-free survival (RFS) rate and risk factors for early recurrence were analyzed.
After a median follow-up of 33.3 months, HCC reoccurred in 105 of 224 patients and 32 died during the period. The 1-, 3- and 5-year OS rates were 97.3%, 81.6% and 75.6% respectively, and the 1-, 3- and 5-year RFS rates were 73.2%, 53.7% and 41.6%. Cox regression showed alpha-fetoprotein (AFP) > 800 ng/ml (HR 2.538, 95% CI 1.464-4.401, P=0.001), multiple tumors (HR 2.286, 95% CI 1.123-4.246, P=0.009) and microvascular invasion (HR 2.518, 95% CI 1.475-4.298, P=0.001) to be associated with early recurrence (recurrence-free time ≤ 1-year) of HCC meeting Milan criteria.
AFP > 800 ng/ml, multiple tumors and microvascular invasion are independent risk factors affecting early postoperative recurrence of HCC. In addition resection appears capable of replacing liver transplantation in some situations with safety and a better outcome.
肝细胞癌（HCC）患者根治性切除术后的预后差异很大。很少有研究调查符合米兰标准的乙型肝炎病毒（HBV）相关HCC早期复发（无复发生存时间≤1年）的危险因素。
对2007年2月至2012年3月间在本中心接受根治性肝切除的224例符合米兰标准的HCC患者进行回顾性分析。分析总生存（OS）率、无复发生存（RFS）率及早期复发的危险因素。
中位随访33.3个月，224例患者中有105例HCC复发，期间32例死亡。1年、3年和5年OS率分别为97.3%、81.6%和75.6%，1年、3年和5年RFS率分别为73.
