Nielsch U, Bisby M A, Keen P
Department of Pharmacology, University of Bristol Medical School, U.K.
Neuropeptides. 1987 Aug-Sep;10(2):137-45. doi: 10.1016/0143-4179(87)90015-1.
Following cutting or crushing the rat sciatic nerve, synthesis of substance P by L5 dorsal root ganglia in vitro was reduced respectively to 20 and 40 per cent of control values. By day 64 the ability to synthesise substance P had been fully restored in crushed neurones but in cut neurones remained at a low level. We conclude that substance P synthesis is a more sensitive index of the effect of nerve injury than is substance P content and further that regenerating axons are able to support substance P synthesis before they reach their target tissue.
切断或挤压大鼠坐骨神经后，L5背根神经节在体外合成P物质的能力分别降至对照值的20%和40%。到第64天时，挤压神经元合成P物质的能力已完全恢复，但切断神经元的合成能力仍维持在低水平。我们得出结论，P物质的合成比P物质的含量更能敏感地反映神经损伤的影响，而且再生轴突在到达其靶组织之前就能支持P物质的合成。
