叠氮胸苷：叠氮基团的晶体结构及可能的功能作用。
Azidothymidine: crystal structure and possible functional role of the azido group.
作者信息
Camerman A, Mastropaolo D, Camerman N
机构信息
Department of Neurology, University of Washington, Seattle 98195.
出版信息
Proc Natl Acad Sci U S A. 1987 Dec;84(23):8239-42. doi: 10.1073/pnas.84.23.8239.
Abstract
The crystal and molecular structures of the anti-acquired immunodeficiency syndrome agent 3'-azido-3'-deoxythymidine (AZT) have been determined by x-ray diffraction. There are two crystallographically independent AZT molecules in the crystal asymmetric unit; they have similar conformations and differ primarily in the glycosyl torsion angle. Comparisons with a hydrated thymidylate structure indicate that the azido group does not significantly affect the gross conformational preference of the molecule. The comparisons also suggest possible functional roles for the azido group in enzyme binding.
摘要
抗获得性免疫缺陷综合征药物3'-叠氮基-3'-脱氧胸苷（AZT）的晶体结构和分子结构已通过X射线衍射测定。晶体不对称单元中有两个晶体学独立的AZT分子；它们具有相似的构象，主要区别在于糖基扭转角。与水合胸苷酸结构的比较表明，叠氮基不会显著影响分子的总体构象偏好。这些比较还表明了叠氮基在酶结合中的可能功能作用。
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Administration of 3'-azido-3'-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex.给艾滋病或艾滋病相关综合征患者使用3'-叠氮-3'-脱氧胸苷，一种HTLV-III/LAV复制抑制剂。
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