Zhang Ke, Yang Zheng-yin, Wang Bao-dui, Sun Shao-Bo, Li Ying-Dong, Li Tian-rong, Liu Zeng-chen, An Jun-mei
College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
Spectrochim Acta A Mol Biomol Spectrosc. 2014 Apr 24;124:59-63. doi: 10.1016/j.saa.2013.12.076. Epub 2014 Jan 4.
A new Schiff-base ligand (1) with good fluorescence response to Al(3+), derived from 2-oxo-quinoline-3-carbaldehyde and nicotinic hydrazide, had been synthesized and investigated in this paper. Spectroscopic investigation revealed that the compound 1 exhibited a high selectivity and sensitivity toward Al(III) ions over other commonly coexisting metal ions in ethanol, and the detection limit of Al(3+) ions is at the parts per billion level. The mass spectra and Job's plot confirmed the 1:1 stoichiometry between 1 and Al(3+). Potential utilization of 1 as intracellular sensors of Al(3+) ions in human cancer (HeLa) cells was also examined by confocal fluorescence microscopy.
本文合成并研究了一种新型席夫碱配体（1），它由2-氧代喹啉-3-甲醛和烟酰肼衍生而来，对Al(3+)具有良好的荧光响应。光谱研究表明，在乙醇中，化合物1对Al(III)离子表现出高于其他常见共存金属离子的高选择性和敏感性，Al(3+)离子的检测限为十亿分之一水平。质谱和乔布氏图证实了1与Al(3+)之间的化学计量比为1:1。还通过共聚焦荧光显微镜检查了1作为人癌细胞（HeLa）中Al(3+)离子细胞内传感器的潜在用途。
