Andersen K, Balldin J, Gottfries C G, Granérus A K, Modigh K, Svennerholm L, Wallin A
Department of Geriatric and Long-term Care Medicine, Vasa Hospital, Gothenburg, Sweden.
Acta Neurol Scand. 1987 Sep;76(3):191-9. doi: 10.1111/j.1600-0404.1987.tb03566.x.
Eleven patients with severe Parkinson's disease and on-off-phenomena were included in a controlled double-blind study on the effect of electroconvulsive therapy (ECT). Pharmacological treatment was optimally adjusted before the trial. The severity of extrapyramidal symptoms was measured before, during and after the treatment. The patients were randomly allocated into one group, receiving active ECT and another, receiving sham treatment. The patients given active ECT showed significantly (P less than 0.05) prolonged duration of "on"-phases after ECT, in comparison to the sham-treated group. When collecting data from the controlled part of the study and the subsequent with open administration of ECT, the treatment was in addition found to significantly decrease the time and number of steps required to walk 10 meters. Moreover it reduced the severity of parkinsonian symptoms according to the Webster scale. The improvement induced by ECT was generally short-lasting. Lumbar punctures were performed before and after ECT. The concentrations of monoamine metabolites in cerebrospinal fluid were not affected by the treatment. The results indicate that ECT has an antiparkinsonian effect which probably is mediated via changed responsiveness of dopamine receptors and that further improvement is possible in patients, therapy resistant to the presently available medication.
11名患有严重帕金森病且存在开关现象的患者被纳入一项关于电休克疗法（ECT）效果的对照双盲研究。在试验前对药物治疗进行了最佳调整。在治疗前、治疗期间和治疗后测量锥体外系症状的严重程度。患者被随机分为两组，一组接受ECT治疗，另一组接受假治疗。与假治疗组相比，接受ECT治疗的患者在ECT治疗后“开”期的持续时间显著延长（P小于0.05）。当从研究的对照部分以及随后开放给予ECT收集数据时，还发现该治疗显著减少了行走10米所需的时间和步数。此外，根据韦伯斯特量表，它降低了帕金森症状的严重程度。ECT诱导的改善通常是短暂的。在ECT治疗前后进行腰椎穿刺。脑脊液中单胺代谢物的浓度不受该治疗的影响。结果表明，ECT具有抗帕金森病作用，这可能是通过多巴胺受体反应性的改变介导的，并且对于目前可用药物治疗耐药的患者可能会有进一步改善。
