Fall P A, Ekman R, Granérus A K, Thorell L H, Wålinder J
Department of Geriatric Medicine, Linköping University, Sweden.
J Neural Transm Park Dis Dement Sect. 1995;10(2-3):129-40. doi: 10.1007/BF02251228.
Electroconvulsive therapy (ECT) was given to 16 non-depressed, non-demented patients with advanced Parkinson's disease (PD). In all the patients an antiparkinsonian effect was seen, lasting for 18 months in one patient, 3-5 months in seven patients, and a few days to four weeks in eight patients. After ECT the levels of homovanillic acid and neuropeptide Y in cerebrospinal fluid (CSF) were significantly increased. The eight patients with long lasting motor improvement after ECT had significantly lower CSF-3-methoxy-4-hydroxyphenylglycol compared to the group with short lasting improvement. Five patients developed transitory mental confusion after ECT. In these patients, and in no others, a high albumin-ratio was found already before ECT was given - an indication of blood CSF barrier damage. Our results suggest that ECT is valuable in patients with drug refractory PD or PD with intolerance to antiparkinsonian drugs.
对16名患有晚期帕金森病（PD）的非抑郁、非痴呆患者进行了电休克治疗（ECT）。所有患者均出现抗帕金森病效应，1例患者持续18个月，7例患者持续3 - 5个月，8例患者持续数天至四周。ECT后，脑脊液（CSF）中高香草酸和神经肽Y水平显著升高。ECT后运动功能长期改善的8例患者的脑脊液3 - 甲氧基 - 4 - 羟基苯乙二醇水平明显低于短期改善组。5例患者在ECT后出现短暂性精神错乱。在这些患者（而非其他患者）中，在给予ECT之前就已发现高白蛋白比值——这表明血脑脊液屏障受损。我们的结果表明，ECT对药物难治性PD或对抗帕金森病药物不耐受的PD患者有价值。
