McFadden Kristina L, Steinmetz Sarah E, Carroll Adam M, Simon Steven T, Wallace Alissa, Rojas Donald C
Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America ; School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.
Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.
PLoS One. 2014 Jan 22;9(1):e85748. doi: 10.1371/journal.pone.0085748. eCollection 2014.
Auditory evoked steady-state responses are increasingly being used as a marker of brain function and dysfunction in various neuropsychiatric disorders, but research investigating the test-retest reliability of this response is lacking. The purpose of this study was to assess the consistency of the auditory steady-state response (ASSR) across sessions. Furthermore, the current study aimed to investigate how the reliability of the ASSR is impacted by stimulus parameters and analysis method employed. The consistency of this response across two sessions spaced approximately 1 week apart was measured in nineteen healthy adults using electroencephalography (EEG). The ASSR was entrained by both 40 Hz amplitude-modulated white noise and click train stimuli. Correlations between sessions were assessed with two separate analytical techniques: a) channel-level analysis across the whole-head array and b) signal-space projection from auditory dipoles. Overall, the ASSR was significantly correlated between sessions 1 and 2 (p<0.05, multiple comparison corrected), suggesting adequate test-retest reliability of this response. The current study also suggests that measures of inter-trial phase coherence may be more reliable between sessions than measures of evoked power. Results were similar between the two analysis methods, but reliability varied depending on the presented stimulus, with click train stimuli producing more consistent responses than white noise stimuli.
听觉诱发稳态反应越来越多地被用作各种神经精神疾病中脑功能和功能障碍的标志物，但缺乏对这种反应的重测信度的研究。本研究的目的是评估听觉稳态反应（ASSR）在不同测试阶段的一致性。此外，本研究旨在探讨刺激参数和所采用的分析方法如何影响ASSR的可靠性。使用脑电图（EEG）在19名健康成年人中测量了间隔约1周的两个测试阶段之间这种反应的一致性。ASSR由40Hz调幅白噪声和短声序列刺激诱发。使用两种独立的分析技术评估不同测试阶段之间的相关性：a）全脑阵列的通道水平分析和b）听觉偶极子的信号空间投影。总体而言，第1阶段和第2阶段之间的ASSR显著相关（p<0.05，经多重比较校正），表明这种反应具有足够的重测信度。本研究还表明，与诱发功率测量相比，不同测试阶段之间的单次试验相位相干性测量可能更可靠。两种分析方法的结果相似，但可靠性因所呈现的刺激而异，短声序列刺激产生的反应比白噪声刺激更一致。
